After a dying Voodoo queen chooses an adopted apprentice as her successor, her true heir is outraged. Seeking revenge, he buys the bones of Blacula the vampire off of a dealer, and uses voodoo to bring the vampire back to do his bidding. In turn, Blacula turns him into a vampire and makes him his slave. Meanwhile, a police officer with a large collection of African antiques and an interest in the occult investigates the murders caused by Blacula and his vampire horde.

An 18th century African prince is turned into a vampire while visiting Transylvania. Two centuries later, he rises from his coffin attacking various residents of Los Angeles and meets Tina, a woman who he believes is the reincarnation of his deceased wife.