Professor Bernard Quatermass is in charge of a rocket mission that has gone awry. They lose contact with the spaceship and have no idea how far into space it may have traveled. When the rocket crash lands they find that only one of the three occupants, Victor Carroon, is on board; the others have simply vanished. Slowly, the surviving astronaut begins to transform into a deadly creature.

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An ancient Martian spaceship is unearthed in London, and proves to have powerful psychic effects on the people around.

Quatermass is the director of an important scientific base, where he builds nuclear rockets for the colonization of the Moon. A strange fall of meteorites in a nearby village leads to the discovery of a huge base under a strict military control, officially a factory of artificial food. Quatermass reveals that the factory is actually breeding alien creatures.