In 1987, a group of film students go scout an abandoned resort in the Pennsylvania wilderness, becoming real victims in another film.

As mass hysteria breaks-out over an alleged demonic possession in an Indiana home, referred to as a “Portal to Hell,” Ghost Adventures host and paranormal investigator Zak Bagans buys the house, sight unseen, over the phone. He and his crew then become the next victims of the most documented case of demonic possession in US history… the “house of 200 demons.

When a medical experiment turns into a blood-soaked nightmare, the only surviving subject flees for her life. Painfully missing her most precious memories of childhood, pummelled by horrific hallucinations, and pursued by those who stand to profit from her damaged brain, Amber Sheridan embarks on a cross-country road trip to track down a mysterious stranger – a man who has the ability to end Amber’s madness, and restore the memories that have been stolen from her.