Ghosts of Mississippi is a drama covering the final trial of the assassin, Bryon De La Beckwith, of the 60s civil rights leader Medgar Evers. It begins with the murder and the events surrounding the two initial trials which both ended in a hung jury. The movie then covers District Attorney, Bobby DeLaughters transformation and alliance with Myrlie Evers, wife of Medgar Evers, of the, as he becomes more involved with bringing Beckwith to trial for the third time 30 years later. Some of the characters are played by the actual participants in this story.

Ethan, a sullen high-school student whose life is defined by what he hates, finds love with a blindly optimistic Christian girl Trinity, much to the annoyance of his angst-filled band mates and her evangelistic brethren.