With Mystery, Inc. on the tail of a strange object in Nowhere, Kansas, the strange hometown of Eustice, Muriel, and Courage, the gang soon find themselves contending with a giant cicada monster and her winged warriors.

Many years after her notorious husband, Henry Fool, fled after killing a neighbor, Fay Grim receives a visit from CIA agent Fulbright, who tells her that Henry is dead, but that some of his journals have been unearthed in France. She sets forth on a globe-trotting odyssey that soon leads to the discovery that he is alive, and his journals are more than they appear to be.

A man wakes up in an alley, bleeding and with no memory of who he is. He stumbles into a coffee shop and is befriended by a charitable ex-nun who is failing in her attempts to write marketable pornography.