After her husband dies, Alice and her son, Tommy, leave their small New Mexico town for California, where Alice hopes to make a new life for herself as a singer. Money problems force them to settle in Arizona instead, where Alice takes a job as waitress in a small diner.

The first remake of the paranoid infiltration classic moves the setting for the invasion, from a small town to the city of San Francisco and starts as Matthew Bennell notices that several of his friends are complaining that their close relatives are in some way different. When questioned later they themselves seem changed, as they deny everything or make lame excuses. As the invaders increase in number they become more open and Bennell, who has by now witnessed an attempted “replacement”, realises that he and his friends must escape or suffer the same fate. But who can he trust to help him and who has already been snatched?

Freelance reporter Jennifer and her two friends, Karen and Vicki, accept an invitation for cheap room and board in a large farmhouse offered by a friendly, but shady, museum owner named Ernest Keller since all the motels in and around town are booked for a holiday parade fair Jennifer is covering. But unknown to the women, some unseen “thing” has been living in the basement of the house for over 20 years and is looked after by Keller and his shy sister Virginia, in which the “thing” soon gets out and begins harassing and killing the women one by one in various violent, but seemingly accidental, means.

An art director in the 1930s falls in love and attempts to make a young woman an actress despite Hollywood who wants nothing to do with her because of her problems with an estranged man and her alcoholic father.