Blood Brother takes place on he mean streets of a city in decay, where a recently released convict begins to take a murderous revenge against his childhood friends, whom he believes let him take the fall for a crime they collectively committed. As the bodies start piling up, one of the friends, now a cop, will stop at nothing to put and end to the murderous rampage and to right the many wrongs of their tragically violent past.

Two teenagers from very different backgrounds awaken to newly acquired superpowers which mysteriously link them to one another.