In 2027 Brazil, civil servant Joana mainly deals with divorce cases. As a member of a branch of evangelical Christians known as the Divino Amor group, she uses her position to offer a kind of physical therapy to couples who want to separate. Although Joana and her husband Danilo regularly consummate their marriage, neither her constant prayers nor any other methods of assistance seem to be able to fulfill their desire for a child.

Bacurau, a small town in the Brazilian sertão, mourns the loss of its matriarch, Carmelita, who lived to be 94. Days later, its inhabitants notice that their community has vanished from most maps.