When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.

Professor Bernard Quatermass is in charge of a rocket mission that has gone awry. They lose contact with the spaceship and have no idea how far into space it may have traveled. When the rocket crash lands they find that only one of the three occupants, Victor Carroon, is on board; the others have simply vanished. Slowly, the surviving astronaut begins to transform into a deadly creature.

Matter-transmitter sabotage leaves a British scientist (Bryant Halliday) disfigured and full of amps.