Madrid, Spain, 1998. The many resources and skills of Gloria, Paz and Sagrario, three middle-aged women investigating paranormal events, are put to the test when their leader, Father Pilón, has an unpleasant encounter.

Pedro, Arturo and Eligio are three college professors who lost their job because of economic crisis. Accidentally they find a solution for all of their problems; a multi-vitamin that allows them to party all night long without any side effects. The three professors will be launched into the world of nightclubs and the shady business, in order to market the merchandise. Of course, it seems that they are not as prepared for it as they thought.