After murdering her young patient, a once-esteemed psychiatrist helplessly watches her life spiral into a nightmarish maelstrom of supernatural hysteria and gruesome deaths, all linked to a seemingly unstoppable ancient curse.

Tim Blake Nelson (The Ballad of Buster Scruggs) is a man who’s safe and comfortable and bored to death with his life. In his state of despair, he looks to classic stories for inspiration. Awakened by the tales of yore, he anoints himself as Don Quixote to find adventure, fame and glory that will make his life worthwhile – all while never leaving his one-mile square neighborhood.