Princeton-Plainsboro Teaching Hospital is turned upside-down when billionaire entrepreneur Edward Vogler buys his way into becoming Chairman of the Board. Vogler intends to use the hospital as a new biotech venture, meaning they no longer require the financially draining services of one Dr. Gregory House.

Meanwhile, a powerful young woman who seemingly has it all – perfect life, perfect body, perfect job – becomes inexplicably paralyzed. Upon discovering her deadly secret, House finds himself fighting for her life even though it means risking his job and his medical license.