A government experiment goes totally wrong as a creature confined in a hidden lab inside and abandoned house escapes. Afterwards, some teens show up to have a little fun in the house, not knowing that the beast is loose and watching them.
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Five college friends have a reunion in a castle in Piemonte, Italy. The local legend says the queen of the castle, Johanna of Anjou, was blamed for the local drought and famine. Before she was hung by the villagers, she placed a curse in her journal then killed herself. The group is intrigued by the legend, and one night when drunk, they enter the forbidden room where Joanna died. There, they find her journal. The spirit of Joanna returns, and her thirst for revenge is horrific.
In a world ravaged by a virus infection, turning its victims into the Undead, Alice continues on her journey to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation reaches new heights, but Alice gets some unexpected help from an old friend. A new lead that promises a safe haven from the Undead takes them to Los Angeles, but when they arrive the city is overrun by thousands of Undead – and Alice and her comrades are about to step into a deadly trap.
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