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Nothing is as it seems as an ex-con and aspirant filmmaker set out to manufacture a horror film by scaring real people; however, when it goes too far and someone actually dies, the pair decide that killing for real on film is the way to make a truly terrifying movie.
Cancer-terminal tycoon Peter Murdoch’s secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device.
After one of their friends commits suicide, strange things begin happening to a group of young Tokyo residents. One of them sees visions of his dead friend in the shadows on the wall, while another’s computer keeps showing strange, ghostly images. Is their friend trying to contact them from beyond the grave, or is there something much more sinister going on?
When a family moves into a San Francisco apartment, an opportunistic troll decides to make his move and take possession of little Wendy (Jenny Beck), thereby paving the way for new troll recruits, the first in his army that will take eventual control of the planet. We soon discover Torok is the ex-husband of Eunice St. Clair, a resident in the building who was married to Torok.
The U.S. government, eager to protect the nation’s avacado supplies, recruits feminist professor Margo Hunt to make contact with the Piranha Women, an all-female tribe who believe men are only good as a source of food. Accompanying Dr. Hunt on her trip are Jim, a guide of questionable competence, and Bunny, a student of unquestionable incompetence.