During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon who explains his mad scientific vision to his captives’ utter horror. They are to be the subjects of his sick lifetime fantasy: to be the first to connect people, one to the next, and in doing so bring to life “the human centipede.”
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Pinhead is trapped in a sculpture and fortunately for him the sculpture is bought by a young playboy who owns his own night club. Pinhead busies himself escaping by getting the playboy to lure victims to his presence so he can use their blood. Once free, he seeks to destroy the puzzle cube so he need never return to Hell, but a female reporter is investigating the grisly murders and stands in his way.
Dawn is an active member of her high-school chastity club but, when she meets Tobey, nature takes its course, and the pair answer the call. They suddenly learn she is a living example of the vagina dentata myth, when the encounter takes a grisly turn.
Workaholic Jim Evers and his wife/business partner, Sara get a call one night from mansion owner, Edward Gracey wants to sell his house. Once the Evers family arrive at the mansion a butler takes them to dine with Gracey. Gracey takes one look at Sara and he thinks she’s his lost lover.
A television crew heads to Nevada to search for alien life.
Presumed dead after a shoot-out with the Haddonfield police, Michael Myers is secretly nursed back to health — and returns a year later to kill again and once more targets his young niece, Jamie. Jamie is now recovering in the local children’s hospital after attacking her stepmother and losing her voice. Her mental link with her evil uncle may be the key to uprooting her family tree.
As a serial killer stalks the city, Julia — a young actress who just moved to town with her husband — notices a mysterious stranger watching her from across the street.